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Substituted ethyl 2-acyl-3-amino-6-methylthieno[2,3-b]pyridine-4-carboxylates as synthons for novel heterocycles

✍ Scribed by Frank T. Coppo; Maged M. Fawzi

Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
199 KB
Volume
34
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

The triethylamine‐catalyzed reaction of 4‐substituted ethyl 2‐acyl‐3‐amino‐6‐methylthieno[2,3‐b]pyridine‐4‐carboxylates IIIa‐h with 2,2,6‐trimethyl‐4__H__‐1,3‐dioxin‐4‐one IV gave 4‐substituted ethyl 3‐acetyl‐2‐hydroxy‐7‐methylthieno[2,3‐b:4,5‐b′]dipyridine‐9‐carboxylates Va‐h. Some of the thienodipyridines (V) reacted with excess IV to give 5‐substituted ethyl 3‐acetyl‐4,8‐dimethyl‐2‐oxo‐2H‐pyrano[2,3‐b]‐pyrido[3′,2′:4,5]thieno[2,3‐e]pyridine‐10‐carboxylates VI.

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