Substituted benzenes and phenols as reversible inhibitors of acetylcholinesterase: Polar, trimethyl, and synergistic effects

Benzene-1,2-, 1,3-, and 1,4-di-N-substit

Benzene-1,2-, 1,3-, and 1,4-di-N-substituted carbamates as conformationally constrained inhibitors of acetylcholinesterase

✍ Ming-Cheng Lin; Mei-Ting Hwang; Han-Ging Chang; Chung-Sheng Lin; Gialih Lin 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 214 KB

## Abstract Benzene‐1,2‐, 1,3‐, and 1,4‐di‐__N__‐substituted carbamates (1–15) are synthesized as the conformationally constrained inhibitors of acetylcholinesterase and mimic __gauche__, __eclipsed__, and __anti__‐conformations of acetylcholine, respectively. All carbamates 1–15 are characterized