✦ LIBER ✦

Substituted benzamides with potential CNS-depressant and hypotensive activity

✍ Scribed by W. D. Roll

Book ID: 102402222
Publisher: John Wiley and Sons
Year: 1970
Tongue: English
Weight: 193 KB
Volume: 59
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600591230

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✦ Synopsis

IJ A series of 14 N-alkyl, N-aryl, and N-aralkyl analogs of N-cyclohexyl nitrobenzamide has been synthesized and chmacterized. The compounds have been studied for their ability to depress the spontaneous motor activity of mice and for their hypotensive activity in rats. Four of the compounds, which are structurally characterized by sniall alkyl groups attached to the amide nitrogen and a p-nitro group, showed the greatest CNS-depressant activity. The hypotensive action of these compounds paralleled their depressant action.

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