✦ LIBER ✦

Substituted alkylpyridines as P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors: Improved pharmacokinetic profiles

✍ Scribed by B. Moon Kim; Colleen M. Hanifin; C. Blair Zartman; Joseph P. Vacca; Stuart R. Michelson; Jiunn H. Lin; I.-W. Chen; Kari Vastag; Paul L. Darke; Joan A. Zugay; Emilio A. Emini; William Schleif; Paul S. Anderson; Joel R. Huff

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 277 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00385-7

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Thiophene derivatives as extremely high

Thiophene derivatives as extremely high affinity P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors

✍ B. Moon Kim; James P. Guare; Joseph D. Vacca; Stuart R. Michelson; Paul L. Darke 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 297 KB

A series of hydroxyethylpiperazine HIV-1 protease inhibitors containing various monocyclic or bicyclic thienylmethyl substituents as Py ligands were prepared. They were found to exhibit extremely high potency in the enzyme inhibition assay. These inhibitors also proved to be highly effective against