Substituted 3-Phenyl-1,3-benzoxazine-2,4-diones and their Bacteriostatic Activity
✍ Scribed by Stenseth, Raymond E.; Baker, Joseph W.; Roman, Daniel P.
- Book ID
- 126262506
- Publisher
- American Chemical Society
- Year
- 1963
- Tongue
- English
- Weight
- 271 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0022-2623
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## Abstract A series of forty-five derivatives of 3-phenyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and forty-five derivatives of 3-phenyl-2H-1,3-benzoxazine-2,4(3H)-dithiones was synthesised. The compounds exhibited in-vitro activity against Mycobacterium tuberculosis, M. kansasii (two strains), and
## Abstract magnified image A series of substituted 5‐, 6‐, 7‐, and 8‐hydroxy‐3‐phenyl‐2__H__‐1,3‐benzoxazine‐2,4(3__H__)‐diones (**5–8**) was synthesized by cyclization of corresponding dihydroxy‐__N__‐phenylbenzamides (**1–4**) with methyl chloroformate. The starting compounds **1–4** were prepa
## Abstract Correlation analysis and, in particular, artificial neural networks (ANN) were used to predict the anti-mycobacterial activity of substituted 3-phenyl-2H-1,3-benzoxazine-2,4(3H)-diones (PBODs) by quantitative structure — activity relationship (QSAR) calculations. Initially, sixty-four d