Substituent effects on oxidation and stabilization of phenothiazine semiquinone free radicals
β Scribed by Thomas N. Tozer; L. Dallas Tuck
- Publisher
- John Wiley and Sons
- Year
- 1965
- Tongue
- English
- Weight
- 634 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0022-3549
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π SIMILAR VOLUMES
The effects of adenosine diphosphate and triphosphate on the periodic acid oxidation of the phenothiazine tranquilizing drugs were studied. The principal effect was a marked reduction in the rate of formation and decay of the drug free radical. The oxidation rates of the nucleotide free drugs seemed
## Abstract Phenothiazine (PtzNH) and phenoxazine (PozNH) can protect human erythrocytes against hemolysis induced by 2,2β²βazobis(2βamidinopropane hydrochloride) (AAPH), a peroxyl radical supplier. However, an antioxidant may be a proβoxidant to accelerate the oxidation in the presence of radicals.
Five aryl-substituted phenacetyl radicals (X = p-MeO, p-Me, H, p-Cl, p-CF 3 ) were generated by laser photolysis of the corresponding dibenzyl ketones in n-hexane and acetonitrile. The decarbonylation reaction was monitored through the rise in time-resolved absorption of the benzyl radical chromopho