Using previously described methods l-5 we have determined the direction and relative rates
Substituent effects on 2-aza-5-hexynyl radical cyclization regiochemistry
β Scribed by Joong-Kwon Choi; David J. Hart; Yeun-Min Tsai
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 186 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
Cyclizations of several N-acyl-2-aza-5-hexynyl radicals are described.
The regiochemical course of these cyclizations depend on the nature of substituents at the alkyne terminus.
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## Abstract Rate constant ratios, __k__~d~/__k__~c~ for the disproportionation/combination reaction have been measured as 0.07 Β± 0.02 when an H is removed from the CH~2~ position of the CF~3~CH~2~CHCH~3~ radical and as 0.24 Β± 0.03 when the H is removed from the CH~3~ position in the reaction with t