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Substituent Effects in the Carboxypeptidase A Catalyzed Hydrolysis of Substituted L,.beta.-Phenyllactate Esters

โœ Scribed by Osumi, Alan; Rahmo, Abdulkader; King, Stephen W.; Przystas, Theodore J.; Fife, Thomas H.


Book ID
127306798
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
928 KB
Volume
33
Category
Article
ISSN
0006-2960

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Carboxypeptidase A-Catalyzed Hydrolysis
โœ S. Lee; B.K. Hwang; Y.C. Myoung; J.H. Suh ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 420 KB

Results of a previous study on the hydrolysis of \(O\)-( \(\alpha\)-acylamino-cinnamoyl)-L- \(\beta\)-phenyllactates \(E 1\) and \(\mathbf{E} 2\) catalyzed by carboxypeptidase \(A(C P A)\) supported the anhydride mechanism for the action of CPA. Since these esters are hydrolyzed very slowly by CPA,