## Abstract The inhibitory effect of recombinant human Cu^++^Zn^++^superoxide dismutase (rhSOD) on metastasis of tumor cells in the mouse was investigated. In an experimental pulmonary metastasis model employing Moth A cells as inoculum, significant inhibition of metastasis was obtained by intraven
Substituent Effect on Proton Affinity of Imidazole in Cu,Zn-Superoxide Dismutase
โ Scribed by Hong-Fang Ji; Hong-Yu Zhang
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 32 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0256-7660
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We used Brownian dynamics simulations of substrate 0, encounters with the enzyme bovine erythrocyte Cu, Zn superoxide dismutase (SOD) to study the effects of multiple charge modifications in the enzyme on the kinetics of its diffusion-controlled reaction. When the charges of two or three residues we
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