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Substance P (SP)-induced desensitization of the neurokinin-1 receptor (NK1-R) and trafficking of G-protein receptor kinases (GRK) and β-arrestin in neurons

✍ Scribed by Corvera, C.U.; McConalogue, K.; Gamp, P.D.; Grady, E.F.; Bunnett, N.W.

Book ID: 122459062
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 202 KB
Volume: 114
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(98)84624-6

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## Abstract Results presented in this study indicate that in human embryonic kidney 293 cells (HEK 293), the ghrelin receptor growth hormone secretagogue receptor type 1a (GHS‐R1a) activates the extracellular signal‐related kinases 1 and 2 (ERK 1/2) via three pathways. One pathway is mediated by th