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Substance P Enhances the Inhibition of Osteoblastic Cell Differentiation Induced by Lipopolysaccharide From Porphyromonas gingivalis

โœ Scribed by Azuma, Hideki; Kido, Jun-ichi; Ikedo, Dai; Kataoka, Masatoshi; Nagata, Toshihiko

Book ID
126939315
Publisher
American Academy of Periodontology
Year
2004
Tongue
English
Weight
301 KB
Volume
75
Category
Article
ISSN
0022-3492

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Porphyromonas gingivalis lipopolysacchar
Porphyromonas gingivalis lipopolysaccharide inhibits the osteoblastic differentiation of preosteoblasts by activating Notch1 signaling
โœ Quan Xing; Qingsong Ye; Mingwen Fan; Yi Zhou; Qiang Xu; Andrew Sandham ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 539 KB

## Abstract Although __Porphyromonas gingivalis__ lipopolysaccharide (Pโ€LPS) is known to inhibit osteoblast differentiation, the exact molecular mechanisms underlying this phenomenon remain unclear. Here, we investigated the role of Notch signaling in the osteoblastic differentiation of both MC3T3E