Substance P Activates Both Contractile and Inflammatory Pathways in Lymphatics Through the Neurokinin Receptors NK1R and NK3R

Neurokinin-1 receptor (NK-1R) expression

Neurokinin-1 receptor (NK-1R) expression is induced in human colonic epithelial cells by proinflammatory cytokines and mediates proliferation in response to substance P

✍ Triona Goode; Terry O'Connor; Ann Hopkins; Derek Moriarty; Gearld C. O'Sullivan; 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 628 KB

## Abstract We have previously shown that the receptor for substance P (SP), neurokinin‐1 receptor (NK‐1R), is a marker of human mucosal but not peripheral mononuclear cells. In the present study, we investigate NK‐1R expression in the human colonic mucosa in vivo, particularly in the epithelial ce