๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Subsequent development of acute non-lymphocytic leukemia in patients treated for Hodgkin's disease

โœ Scribed by J. W. van der Velden; W. L. J. van Putten; V. F. Guinee; R. Pfeiffer; F. E. van Leeuwen; E. A. M. van der Linden; I. Vardomskaya; W. Lane; M. Durand; C. Lagarde; F. B. Hagemeister; A. Hagenbeek; H. Eghbali

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
481 KB
Volume
42
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

A nested case control study was carried out to investigate the association between treatment of patients with Hodgkin's disease (HD) and the risk of developing acute non-lymphocytic leukemia (ANLL). Seven Cancer Centers of the International Cancer Patient Data Exchange System of the UlCC participated. A study cohort was selected consisting of 1,681 nonpretreated patients with HD, diagnosed from 1972 through 1978, and followed up through 1984. The median follow-up time was 66 months. Eighteen cases of leukemia were observed in the cohort. The risk of development of ANLL was significantly greater for male than for female patients. The treatment characteristics associated with an increased risk of developing ANLL were extensive radiotherapy, splenectomy and the chemotherapy combination of vincristine. procarbazine and mechlorethamine.

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