Subretinal administration of tissue-type plasminogen activator to speed the drainage of subretinal hemorrhage
β Scribed by S. Saika; Akifumi Yamanaka; Akio Yamanaka; Ayako Minamide; Keisyu Kin; Kumi Shirai; Sai-ichi Tanaka; Yoshiji Kawashima; Tadashi Katoh; Yuka Okada; Kiyomi Ohkawa; Yoshitaka Ohnishi
- Publisher
- Springer-Verlag
- Year
- 1998
- Tongue
- English
- Weight
- 805 KB
- Volume
- 236
- Category
- Article
- ISSN
- 0065-6100
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Using 1.2kb 3'-terminal Pst-I fragment of a full length tissue-type plasminogen activator (t-PA) cDNA clone (ptPA-8FL) and a set of rodent human somatic cell hybrids, the corresponding human gene PLAT was localized on chromosome 8.
Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit