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Subregional localization of the chromosome 21 loci D21S24 and D21S26 using physical mapping techniques

✍ Scribed by Wim Hul; Hubert Backhovens; Guy Camp; Piet Stinissen; Marc Cruts; Anita Wehnert; Christine Broeckhoven

Book ID: 104662651
Publisher: Springer
Year: 1991
Tongue: English
Weight: 508 KB
Volume: 87
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00204162

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✦ Synopsis

We were able to refine the chromosomal position of two existing marker loci, using an extended chromosome 21 somatic cell hybrid panel. The locus D21S26 mapped in the region 21q11.2-q21.1, and the locus D21S24 in 21q22.1-q22.2. Physical and genetic analysis indicated that D21S26 is tightly linked to D21S13 and D21S16, two markers previously linked to familial Alzheimer's disease.

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