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Subnuclear Localization of Protein Kinase C δ in Beta Cells

✍ Scribed by Keith L. Knutson; Margarethe Hoenig

Book ID
112238230
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
234 KB
Volume
62
Category
Article
ISSN
1077-3150

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Regulation of distinct pools of protein
Regulation of distinct pools of protein kinase C δ in beta cells
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Previous studies from our laboratory have demonstrated the presence of several isoforms of protein kinase C (PKC), Caz+-independent and Ca2+-dependent, in both whole islets and tumor-derived beta cells. In the basal state, a major proportion of the isoform was found in the crude membrane fraction wi

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✍ Keith L. Knutson; Margarethe Hoenig 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 954 KB

We have previously identified expression of multiple protein kinase C (PKC) isoforms in insulinomaderived beta-cells and whole islets. Both PKC 6 and PKC a appear to be the more abundantly expressed isoforms. in this report we studied the effects of arachidonic acid (AA) on the subcellular distribut