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Subnormal secretion of parathyroid hormone prevents age-related bone loss

✍ Scribed by Kaoru Fujiyama; Takeshi Kiriyama; Masako Ito; Hironori Kimura; Masako Tsuruta; Kiyoto Ashizawa; Yuji Nagayama; Sumiaki Okamoto; Naokata Yokoyama; Shunichi Yamashita; Shigenobu Nagataki

Publisher
Springer
Year
1994
Tongue
English
Weight
176 KB
Volume
12
Category
Article
ISSN
0914-8779

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## Abstract Secreted frizzled‐related protein (sFRP)‐1 is a Wnt antagonist that when deleted in mice leads to increased trabecular bone formation in adult animals after 13 weeks of age. Treatment of mice with parathyroid hormone (PTH) also increases trabecular bone formation, and some of the anabol