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Submicroscopic Insertion of RARα Gene into Chromosome 15 in Two Cases of Acute Promyelocytic Leukemia

✍ Scribed by F Viguié; A Aboura; S Ramond; D Bouscary; M Baudard; C Chomienne; J.P Marie


Book ID
114137058
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
348 KB
Volume
119
Category
Article
ISSN
0165-4608

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✍ Yongsheng Han; Yongquan Xue; Jun Zhang; Jinlan Pan; Yafang Wu; Shuxiao Bai 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 316 KB

Acute promyelocytic leukemia (APL) is characterized by the presence of a chromosomal rearrangement involving retinoic acid receptor alpha (RARalpha) gene generating the X-RARalpha fusion. We describe here a unique RARalpha gene rearrangement in a patient with M3r subtype of APL. Conventional cytogen