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Sublingual Immunotherapy Induce Systemic T-cell Tolerance in Naive Mice

✍ Scribed by Brimnes, J.; Kildsgaard, J.; Jacobi, H.; Lund, K.


Book ID
119278184
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
51 KB
Volume
119
Category
Article
ISSN
1097-6825

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Antigen-specific T cell tolerance can be induced by systemic injection of high-dose antigen. In particular, a single intravenous (i.v.) injection of influenza virus hemagglutinin peptide in HNT-TCR transgenic mice induces T cell tolerance through thymocyte apoptosis as well as anergy and deletion of