Subjective effects of narcotic antagonists cyclazocine and nalorphine on the Addiction Research Center Inventory (ARCI)

✍ Scribed by Charles A. Haertzen

• Publisher: Springer
• Year: 1970
• Tongue: English
• Weight: 680 KB
• Volume: 18
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00402763

✦ Synopsis

The subjective effects of two doses of eyclazocine (0.6 mg and 1.2 mg/70 kg), nalorphinc (16 and 32 mg/7O kg), no-drug and placebo were compared with 32 opiate addicts using drug sensitive scales of the Addiction Researeh Center Inventory (ARCI) items. The effects of these nareotie antagonists were highly similar on ARCI scales and items. Both drugs produced a general drug effect, difficulty in focusing eyes, physical weakness, tiredness, poor motivation, moodiness, misery, anxiety, tension, hallucinations, changes in sensation and perception, and inefficiency of physical, cognitive and social functions. Cyclazocine was 15--26 times more potent than nalorphine. The effects of cyclazocine and nalorphine were differentiated from the effects of other drugs such as morphine, pentobarbital and LSD when the overall pattern of effect was considered.