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Basicity Acidity dicarboxylic acids, 175 imidazole in cis-urocanic acid derivatives, steric enhancement, 323 Acylation Ν°-chymotrypsin by N-acylimidazoles, effect of proton sponges, 175 leaving group, 119 Bicarbonate N-Acylimidazoles dehydration to carbon dioxide, role of caracylation of Ν°-chymotrypsin, effect of leaving bamoyl phosphate synthetase (Escherichia group, 119 coli), 255 Addition reactions Biotin oxidative, resorufin derivatives with 2-mercaptovitamers of, synthesis, 157 ethanol, 63 Bovine serum albumin Alcohol dehydrogenase thiol groups in, electrostatic environments of, binding of inhibiting adducts of ketones and characterization with kinetic approach, 356 NAD Ο© (Drosophila melanogaster), 233 Breast cancer cells Aldehyde dehydrogenase growth in culture, inhibition by cyclopropyl anacytosolic, and resorufin derivatives, covalent logues of antiestrogen MER 25, 15 modification reactions involving, 75 ΝΆ-Bromoalkane-carboxylate ions Alzheimer's disease lactone formation from, enthalpy and entropy, research importance of 3,4-dihydroxyphenylace-193 taldehyde, 45 Aminoacylation C tRNA Glu , catalyzed by glutamyl-tRNA synthetase, inhibition by glutamyl adenylate ana-Carbamoyl phosphate synthetase logues, 1 role in dehydration of bicarbonate to carbon 5-(2-Aminoethyl)-dithio-2-nitrobenzoate dioxide (Escherichia coli), 255 synthesis and reactions with thiol groups, 356 Carbon dioxide Antiestrogens formation by bicarbonate dehydration, role of MER 25, cyclopropyl analogues of, synthesis and carbamoyl phosphate synthetase (Eschebiological evaluation, 15 richia coli), 255 Antitubercular agents Carboxylate group 1,3,4-thiadiazolyl-substituted 1,2,4-triazines, miin 4-oxalocrotonate tautomerase substrate, concrowave-assisted synthesis, 289 tribution to reaction mechanism, 141 Aprotic solutions Carboxypeptidase A dicarboxylic acids, low-barrier hydrogen bondactive site, lowest-energy conformation of subing in, spectroscopic study, 213 strates in, search by Monte Carlo/energy Aqueous solutions minimization techniques, 295 azaguanine tautomerism and protonation in, Chiral separation theoretical study, 345 tryptophan, phenylalanine, and histidine using dicarboxylic acids, low-barrier hydrogen bondpolymeric transporters prepared by molecing in, spectroscopic study, 213 ular imprinting, 309 strong hydrogen bonds in, 175 Chloride Artificial enzymes S N 2 displacement from 1,2-dichloroethane at site-directed functionalization, 51 haloalkane dehalogenase active site, en-Azaguanine zyme-substrate complex and transition tautomerism and protonation in gas phase and aqueous solution, theoretical study, 345 state structures in, 169
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