Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers
β Scribed by Khalid Iqbal; Michael Flory; Sabiha Khatoon; Hilkka Soininen; Tuula Pirttila; Maarit Lehtovirta; Irina Alafuzoff; Kaj Blennow; Niels Andreasen; Eugeen Vanmechelen; Inge Grundke-Iqbal
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 516 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0364-5134
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π SIMILAR VOLUMES
## Abstract ## Objectives The aim of this longitudinal study was to test the hypothesis that CSF biomarkers in AD patients also may be forwardβlooking measures that are associated not only with the degree and profile of cognitive impairment but also with changes in cognition over time. ## Methods
Monoamine metabolites, biopterin, acetylcholinesterase (AChE) activity, and somatostatin-like immunoreactivity (SLI) were determined in the lumbar cerebrospinal fluid (CSF) of 24 patients with dementia of the Alzheimer type (DAT) without myoclonus or extrapyramidal signs, in 8 patients with DAT and