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Subgrouping of DR4 alleles by DNA heteroduplex analysis

โœ Scribed by Sorrentino, Rosa; Cascino, Isabella; Tosi, Roberto


Book ID
123167510
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
623 KB
Volume
33
Category
Article
ISSN
0198-8859

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DNA molecules derived from three alleles of the HLA-DRB3 locus and differing from each other at several nucleotide sites were denatured and cross-hybridized. Each allelic combination was found to generate a pair of heteroduplexes of different mobility. Their retardation as compared to homoduplexes w