In several retrospective post-mortem studies, patients meeting clinical criteria for Alzheimer's disease (AD) who gained the greatest cognitive bene®t from treatment with an acetylcholinesterase (AChE) inhibitor were found to have neocortical Lewy bodies accompanying classical AD neuropathology. Thi
Subclinical dementia. Relation to cognition, personality and psychopathology: A nine-year prospective study
✍ Scribed by Dr.; Associate Professor Göran Persson; Professor Stig Berg; Lars Nilsson; Professor Alvar Svanborg
- Book ID
- 102845916
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 711 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0885-6230
No coin nor oath required. For personal study only.
✦ Synopsis
In 1971/72 a representative sample of 70-year-olds was studied by means of psychological tests and personality inventories. Subjects showing evidence of dementia were excluded. Those who developed severe dementia between the ages of 70 and 79 were compared with those who did not. At 70, males subsequently developing dementia scored lower on a test of reasoning and on a test of perceptual speed, and needed more time to complete their tests than did the other males. At the same age, females subsequently developing dementia were slow on some of the tests, scored lower on a personality dimension pertaining to available resources of mental energy and scored higher on a personality dimension pertaining to a need to keep other people at a distance than did the other females. A logistic regression analysis demonstrated that the time taken to complete some of the cognitive tests and the personality dimension pertaining to mental energy independently predicted the development of severe dementia. There were no differences with regard to psychiatric diagnoses. The question whether these findings might be interpreted as early manifestations of dementia or as predisposing factors is as yet unanswered.
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## Abstract ## Objective By means of a representative follow‐up survey, we investigated changes in family physicians' (FPs) attitudes towards cognition enhancers in early dementia during 1993 and 2001. ## Methods One hundred and twenty‐two FPs (response rate 71.8%) in Lower Saxony, Germany, were