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Subchronic toxicology of butyl nitrites in mice by inhalation

✍ Scribed by David P. McFadden; Roger P. Maickel

Book ID: 102872338
Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 544 KB
Volume: 5
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550050303

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✦ Synopsis

Mice were exposed by inhalation to n-butyl, iso-butyl sec-butyl or tert-butyl nitrite in a dynamic airflow chamber 7 h per day for 60 days at concentrations that caused less than 20% fatalities. Under these conditions, body-weight gain was depressed over the first 30 days by all four compounds, but returned to normal over the final 30 days for all compounds except tert-butyl nitrite. Spleen weights were increased by all four butyl nitrites, and lung weights were increased by all except sec-butyl nitrite. Kidney weights were increased by iso-butyl and sec-butyl nitrites, but decreased by the tert-butyl compound. Liver weights were increased by iso-butyl nitrite exposure and decreased by tert-butyl nitrite exposure. The results are consistent with the hypothesis that a significant aspect of butyl nitrite toxicity is due to the resultant methemoglobinemia.

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