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Subchronic toxicity of all-trans-retinoic acid and retinylidene dimedone in Sprague-Dawley rats

✍ Scribed by Perry J. Kurtz; Donald C. Emmerling; David J. Donofrio

Book ID
103655551
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
620 KB
Volume
30
Category
Article
ISSN
0300-483X

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## Abstract Biodegradable microspheres containing all‐__trans__‐retinoic acid (atRA) were prepared previously to enhance the clinical efficacy of atRA for chemoprevention. In this study, subacute toxicity of atRA in sustained release was evaluated after subcutaneous administration of 0, 25, 50, and