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Subchronic oral toxicity of strychnine in rats

✍ Scribed by Ivan Seidl; Gerhard Zbinden

Publisher: Springer-Verlag
Year: 1982
Tongue: English
Weight: 277 KB
Volume: 51
Category: Article
ISSN: 0340-5761
DOI: 10.1007/bf00348858

No coin nor oath required. For personal study only.

✦ Synopsis

In recent years strychnine has been used for the treatment of nonketotic hyperglycinemia, a rare metabolic disease in infants. Since no information on repeated dose toxicity of this drug was available, a subacute oral toxicity study in rats was conducted. Strychnine hydrochloride was administered orally to rats for 4 weeks in aqueous 0,2 % solution. The study showed no organ and tissue damage or functional disorders. The difficulty to conduct meaningful repeated-dose toxicity studies with drugs exhibiting potent pharmacological actions and a steep dose-effect curve are discussed.

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