OECD GUIDELINE FOR THE TESTING OF CHEMICALS
SUMMARY
This revised Test Guideline 413 (TG 413) has been designed to fully characterize test article toxicity by the inhalation route for a subchronic duration (90 days), and to provide robust data for quantitative inhalation risk assessments. Groups of 10 ...
INTRODUCTION
INITIAL CONSIDERATIONS
DESCRIPTION OF THE METHOD
Selection of Animal Species
Preparation of Animals
Animal Husbandry
Inhalation Chambers
TOXICITY STUDIES
Limit Concentrations
Range-Finding Study
Main Study
Interim Sacrifices
Satellite (Reversibility) Study
Control Animals
EXPOSURE CONDITIONS
Administration of Concentrations
19. Animals are exposed to the test article as a gas, vapour, aerosol, or a mixture thereof. The physical state to be tested depends on the physico-chemical properties of the test article, the selected concentrations, and/or the physical form most li...
Particle-Size Distribution
Test Article Preparation in a Vehicle
MONITORING OF EXPOSURE CONDITIONS
Chamber Airflow
Chamber Temperature and Relative Humidity
Test Article: Nominal Concentration
Test Article: Actual Concentration
Test Article: Particle Size Distribution
OBSERVATIONS
BODY WEIGHTS
FOOD AND WATER CONSUMPTION
CLINICAL PATHOLOGY
OPHTHALMOLOGICAL EXAMINATION
GROSS PATHOLOGY AND ORGAN WEIGHTS
HISTOPATHOLOGY
DATA AND REPORTING
Data
Test Report
Test animals and husbandry
Test article
Vehicle
Inhalation chamber
Exposure data
Test conditions
Results
Discussion and interpretation of results