✦ LIBER ✦

Subchronic feeding study of antimony trioxide in rats

✍ Scribed by P. M. Hext; P. J. Pinto; B. A. Rimmel

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 52 KB
Volume: 19
Category: Article
ISSN: 0260-437X
DOI: 10.1002/(sici)1099-1263(199905/06)19:3<205::aid-jat567>3.0.co;2-x

No coin nor oath required. For personal study only.

✦ Synopsis

Diets containing antimony trioxide were fed to male and female Wistar rats of the Alpk:APSD strain over 90 days. Dose levels were 0 (control), 1000, 5000 and 20,000 ppm (equivalent to mean daily doses of 84, 421 and 1686 mg kg(-1) in males and 97, 494 and 1879 mg kg(-1) in females). There was no effect of compound on growth or growth rate, food consumption or clinical signs. Minor changes in haematology and urine biochemistry were considered incidental to treatment. Small reductions in plasma alkaline phosphatase activity and increases in aspartate aminotransferase activity at the high dose, together with a small (ca. 10%) increase in liver weight, could be indicative of a minor effect on the liver, but in the absence of any histological effects these changes are also considered incidental to treatment. This study confirms the inert nature of antimony trioxide.

📜 SIMILAR VOLUMES

Subchronic inhalation neurotoxicity stud

Subchronic inhalation neurotoxicity study of amyl acetate in rats

✍ Michael W. Gill; Tipton R. Tyler; Peter C. Beyrouty 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 82 KB 👁 2 views

Behavioral effects of subchronic inorgan

Behavioral effects of subchronic inorganic manganese exposure in rats

✍ T. Vezér; A. Kurunczi; M. Náray; A. Papp; L. Nagymajtényi 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 225 KB 👁 1 views

Subchronic toxicity of PCB 105 (2,3,3′,4

Subchronic toxicity of PCB 105 (2,3,3′,4,4′-pentachlorobiphenyl) in rats

✍ I. Chu; R. Poon; A. Yagminas; P. Lecavalier; H. Håkansson; V. E. Valli; S. W. Ke 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 81 KB 👁 1 views

2,3,3Ј,4,4Ј-pentachlorobiphenyl; PCB 105; subchronic toxicity; rat The toxicity of 2,3,3Ј,4,4Ј-pentachlorobiphenyl (PCB 105) was investigated in Sprague-Dawley rats following dietary exposure to this substance at levels of 0, 0.05, 0.5, 5 or 50 ppm for 13 weeks. Growth rate and food consumption wer

Subchronic inhalation toxicity of 3.5-μm

Subchronic inhalation toxicity of 3.5-μm diameter carbon fibers in rats

✍ R. S. Waritz; B. Ballantyne; J. J. Clary 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 110 KB 👁 1 views

No effects were seen when rats were exposed for 6 h day ؊1 , 5 days per week, for 16 weeks to an atmosphere of 20 mg m ؊3 of carbon fibers (25 × 10 6 fibers m ؊3 ) and small amounts of fiber particulate resulting from preparation of the ultimate test material. The carbon fibers were made from polyac

Dominant lethal study of Spirulina maxim

Dominant lethal study of Spirulina maxima in male and female rats after short-term feeding

✍ Gérman Chamorro; María Salazar; Nicole Pages 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 400 KB 👁 1 views

The algae SpiruLina maxima has been considered for use as a supplementary protein in feed and food, as well as an hypocholesterolaemic and antiherpes simplex virus agent. In this paper the mutagenic potential was investigated in animals of each sex. Sexually mature male or female Wistar rats, receiv

Effects of feed restriction on fertility

Effects of feed restriction on fertility in female rats

✍ K.K. Terry; L.A. Chatman; G.L. Foley; E. Kadyszewski; T.L. Fleeman; M.E. Hurtt; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 194 KB 👁 1 views

## Background: Feed restriction with its resultant body weight loss impacts the rodent estrous cycle; however, the manifestation of these changes in a regulatory study design has not been documented. this study reports the effects of feed restriction in the context of an fda regulatory submission.