✦ LIBER ✦

Subcellular localization and quantitative analysis of Toxoplasma gondii target antigens of specific immunoglobulins G, M, A, and E

✍ Scribed by E. Kumolosasi; Dr. A. Bonhomme; H. Lepan; C. Marx; F. Foudrinier; J. M. Pinon; A. Beorchia; M. Pluot

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 972 KB
Volume: 29
Category: Article
ISSN: 1059-910X
DOI: 10.1002/jemt.1070290309

No coin nor oath required. For personal study only.

✦ Synopsis

The target antigens of specific immunoglobulins G, M, A, and E from patients with acquired acute toxoplasmosis were determined using immunocytochemistry. The relative repartition of these antigens in four cellular compartments of Toxoplasma (membrane complex, apical area, rhoptries, and dense granules) was quantitatively evaluated. Rhoptry antigens mainly react positively with IgA. Membrane, submembrane area (membrane complex), and rhoptry antigens are immunodominant for IgA and IgM. Apical area antigens are recognized by IgM two times more than IgG and IgA. IgE recognized only rhoptry antigens.

The localization of pathogenetically antigenic components and their identification by the immune system appeared to be of importance for selection of immunodominant or recombinant antigens. Such localization would improve laboratory diagnosis of serious congenital toxoplasmosis or in immunocompromised patients with toxoplasmic complications after cyst reactivation.

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