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Subcellular distribution of small GTP-binding proteins in the intestinal cell line Caco-2

✍ Scribed by J. STEIN; R. GERHARD; S. ZEUZEM; W. F. CASPARY


Book ID
114727503
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
289 KB
Volume
25
Category
Article
ISSN
0014-2972

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi