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Subcellular distribution of p210BCR-ABL in CML cell lines and primary CD34+ CML cells

✍ Scribed by Patel, H; Marley, S B; Greener, L; Gordon, M Y


Book ID
110058567
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
764 KB
Volume
22
Category
Article
ISSN
0887-6924

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## Abstract Chronic myeloid leukemia (CML) arises as a consequence of the expression of a chimeric fusion protein, p210BCR‐ABL1, which is localized to the cytoplasm and has constitutive protein tyrosine kinase activity. Extensive publications report that p210BCR‐ABL1 complexed with multiple cytopla