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Subcellular distribution of catechol-O-methyltransferase in amelanotic and melanotic malignant melanoma

✍ Scribed by Shibata, Takakazu; Pavel, Stan; Ichihashi, Masamitsu; Mishima, Yutaka


Book ID
122371727
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
124 KB
Volume
2
Category
Article
ISSN
0923-1811

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## Abstract Prolonged exposure to unopposed estrogens is a major risk factor for the development of endometrial cancer. Oxidative metabolism of estradiol (E~2~) into the catecholestrogens (CEs), 4‐hydroxyestradiol (4‐OHE~2~) and 2‐hydroxyestradiol (2‐OHE~2~), may play an important role in estrogen