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Subacute myelopathy: An unusual paraneoplastic complication of Hodgkin's disease

✍ Scribed by Dansey, R. D. ;Hammond-Tooke, G. D. ;Lai, K. ;Bezwoda, W. R.

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 262 KB
Volume: 16
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950160413

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✦ Synopsis

We report a case of Hodgkin disease presenting with a subacute myelopathy without evidence of metastatic involvement of the spinal cord. The systemic disease responded to conventional chemotherapy, but the myelopathy only improved after intrathecal dexamethasone was added to the treatment program, beta-2-microglobulin levels in the cerebrospinal fluid were elevated at presentation. Following the use of intrathecal corticosteroids there was a decrease of CSF beta-2-microglobulin levels. The possible significance of these findings is discussed.

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