✦ LIBER ✦
Subacute (4-week) inhalation toxicity study of formaldehyde in male rats: 8-hour intermittent versus 8-hour continuous exposures
✍ Scribed by J. W. G. M. Wilmer; R. A. Woutersen; L. M. Appelman; W. R. Leeman; V. J. Feron
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 232 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0260-437X
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✦ Synopsis
Male Wistar rats were exposed for 4 weeks, 5 days a week, to 0 (controls), 5 or 10 ppm formaldehyde continuously (8 hours a day), or to 10 or 20 ppm formaldehyde interruptedly (eight 30 min exposure periods separated by 30 min non-exposure periods). Histopathology and cell proliferation studies indicated that under the conditions of exposure used, concentration rather than the total dose of formaldehyde determined the severity of the cytotoxic effects on the nasal epithelium.