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Sub-chronic toxicity study in rats orally exposed to nanostructured silica

✍ Scribed by van der Zande, Meike; Vandebriel, Rob J; Groot, Maria J; Kramer, Evelien; Herrera Rivera, Zahira E; Rasmussen, Kirsten; Ossenkoppele, Jan S; Tromp, Peter; Gremmer, Eric R; Peters, Ruud JB; Hendriksen, Peter J; Marvin, Hans JP; Hoogenboom, Ron LAP; Peijnenburg, Ad ACM; Bouwmeester, Hans

Book ID
121550300
Publisher
BioMed Central
Year
2014
Tongue
English
Weight
916 KB
Volume
11
Category
Article
ISSN
1743-8977

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Sub-acute versus sub-chronic oral toxici
Sub-acute versus sub-chronic oral toxicity study in rats: Comparative study of 82 compounds
✍ Rund A. Woutersen; Heero P. Til; Victor J. Feron πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 English βš– 376 KB

Toxicity data of 82 compounds, tested in both B sub-acute and a sub-chronic study, were evaluated to find out whether it is possible to substitute a sub-acute for a sub-chronic study without losing quantitative information. The no-effect level (NEL) and the minimal-effect level (MEL) were used as th