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Su.62. A Clonal Model for Human CD8 Regulatory T Cells: Unrestricted Contact-dependent Killing of Activated CD4 T Cells

✍ Scribed by Dan Hu; Xia Liu; Wanyong Zeng; Jerome Ritz

Book ID
113540553
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
38 KB
Volume
127
Category
Article
ISSN
1090-2341

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## Abstract Treatment with anti‐CD3 mAb modulates immune responses that cause type 1 diabetes and other diseases. CD8^+^ Tregs can be induced in vitro and in vivo by mAb. However, 1/3 of patients do not respond to drug therapy and in an equal proportion, anti‐CD3 mAb does not induce Tregs in vitro.