Su.41. Th2 T-Cell Clones from Tcr Transgenic Mice Are Diabetogenic
β Scribed by Jing He; Kathryn Haskins
- Book ID
- 113539338
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 56 KB
- Volume
- 119
- Category
- Article
- ISSN
- 1090-2341
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π SIMILAR VOLUMES
## Abstract To investigate regulatory mechanisms which naturally prevent autoimmune diseases, we adopted the genetically restricted immunodeficient (RAGβ1^β/β^) myelin basic protein (MBP)βspecific T cell receptor (TCR) double transgenic (T/Rβ) mouse model of spontaneous experimental autoimmune ence
Our analysis of TCR V gene usage in mice transgenic for the Vb8.2 gene has demonstrated that T cells isolated from the spinal cord of these transgenic mice during active experimental autoimmune encephalomyelitis were significantly biased for Va2 expression. This Va2 bias was noted in T cells derived