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Su1594 Regulation and Function of Methionine Adenosyltransferases in Quiescent and Activated Human Hepatic Stellate Cells

โœ Scribed by Park, Sunhee; Tomasi, Maria Lauda; Ramani, Komal

Book ID
122125862
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
57 KB
Volume
142
Category
Article
ISSN
0016-5085

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Hepatic stellate cell (HSC) activation is an essential event during liver fibrogenesis. Methionine adenosyltransferase (MAT) catalyzes biosynthesis of S-adenosylmethionine (SAMe), the principle methyl donor. SAMe metabolism generates two methylation inhibitors, methylthioadenosine (MTA) and S-adenos