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Styryl-lactone derivatives and alkaloids from Goniothalamus borneensis (Annonaceae)

✍ Scribed by Shu-Geng Cao; Xiao-Hua Wu; Keng-Yeow Sim; B.K.H. Tan; J.T. Pereira; Swee-Hock Goh

Book ID: 104208321
Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 545 KB
Volume: 54
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(97)10422-7

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✦ Synopsis

Twelve natural products, including two new compounds, goniothalesdiol la and goniothalactam 2, were isolated from the bark of the Malaysian tree Goniorhalumus borneensis (Annonaceae) and evaluated for their cytotoxic activity. Their structures were elucidated by spectroscopy including 2D-NMR spectroscopy. la, which was semisynthesised from (+)-goniothalenol(3a), was related to several cytotoxic styryl-lactones (4 -8) also isolated from this species.

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