Study on the synthesis of brassinolide a
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Wei-Shan Zhou; Wei-Sheng Tian
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Article
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1987
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Elsevier Science
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French
โ 450 KB
Typhasterol 2 was synthesized stereoselectively from hyodeoxycholic acid 3. The aldehyde 5 derived from 3 was reacted with the anion of 3-methylbutenolide under kinetic condition to afford (22R,23R)-7 as the major product. Hydrogenation of 7 and its 22-acetate 14 over PtO2-Pt/C yielded the expected