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Study on the possible involvement of protein kinases in the modulation of brain presynaptic sodium channels; comparison with calcium channels

✍ Scribed by Maria Sitges; Fernando Peña; Luz Maria Chiu; Araceli Guarneros


Book ID
117410283
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
556 KB
Volume
32
Category
Article
ISSN
0197-0186

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Both the neuronal IIA as well as the cardiac SkM2 isoform of the pore forming alpha-subunit of voltage dependent sodium channels are modulated by Protein Kinase A. While alphaIIA becomes attenuated upon PKA stimulation, alphaSkM2 becomes upregulated. PKC dependent phosphorylation of a serine, locate