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Study on the enzymatic hydrolysis of racemic methyl ibuprofen ester

✍ Scribed by M Venu Madhav; C B Ching


Publisher
Wiley (John Wiley & Sons)
Year
2001
Tongue
English
Weight
226 KB
Volume
76
Category
Article
ISSN
0268-2575

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Theoretical studies on the acid hydrolys
✍ Ikchoon Lee; Chang Kon Kim; Byung Choon Lee 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 499 KB

The mechanism of the A2 acid hydrolysis of methyl carbamate was investigated using MNDO method. The reaction was found to proceed in two steps: (1) the rate-determining nucleophilic attack of water on the carbonyl carbon of the N-protonated tautomer involving the tetrahedral TS; and (2) the fast sub