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Study on in situ and in vivo absorption kinetics of phenytoin by modulating P-glycoprotein with verapamil in rats

โœ Scribed by Prasad Neerati; Dinesh Ganji; Sathish Kumar Bedada


Book ID
113592468
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
285 KB
Volume
44
Category
Article
ISSN
0928-0987

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โœ Manthena V.S. Varma; Ramesh Panchagnula ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 180 KB ๐Ÿ‘ 1 views

The purpose of this study is to determine the functional role of P-glycoprotein (P-gp) in intestinal absorption of drugs and to quantitatively predict the in vivo absorption enhancement on P-gp inhibition. In situ single-pass rat ileum permeability and aqueous solubility were measured for a set of 1