The IodineeSulfur (IS) thermo-chemical process for the production of hydrogen is one of the most promising approaches for use of the high temperature process heat supplied by high temperature reactor, which was developed in the Institute of nuclear and new energy technology (INET) of Tsinghua University, China, and INET initiated the fundamental studies on IS cycle since 2005. Based on the experiment results obtained by fundamental researches, a lab-scaled closed cycle loop (IS-10), which featured in electro-electrodialysis (EED) for hydriodic acid (HI) concentration, was designed and built at INET. The loop was composed of three sections, i.e., Bunsen section, HI section and sulfuric acid section. The closed cycle experiment on the loop was successfully carried out recently. In HI section, HI x produced by Bunsen reaction was continuously purified through reverse Bunsen reaction, concentrated by EED, and then HI solution was obtained by distillation. Finally HI was catalytically decomposed to H 2 and I 2 with the conversion of 20%. In sulfuric acid section, sulfuric acid was continuously purified, concentrated by distillation, and catalytically decomposed to SO 2 , O 2 and H 2 O with the conversion of 75%. In Bunsen section, water, including recycled water, reacted with I 2 and SO 2 recycled from HI section and sulfuric acid section to form two separated acids phases, thus to form a closed cycle. The closed cycle experiment lasted for 7 h with the hydrogen production rate of 10 NL/h, with Pt loaded on activated carbon and copper chromite used as the catalysts for HI and sulfuric acid decomposition, respectively. This paper summarizes the main features of IS-10 and the main results of the closed cycle experiment. So far IS-10 is the second reported facility on which closed experiment was carried out, and the first one with EED embedded to perform a closed cycle operation.