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Study of the stability of pyrimidine series cytostatics, ftorafur and fluorouracil injections

✍ Scribed by Hana Tománková; Jaroslav Zýka

Book ID
107828713
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
675 KB
Volume
22
Category
Article
ISSN
0026-265X

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## Abstract The geometries of a 13 mer of a DNA double helix (5′‐GCGTAC**A**CATGCG‐3′) were determined by molecular dynamics simulations using a Cornell et al. empirical force field. The bases in the central base pair (shown in bold) were replaced (one or both) by a series of hydrophobic base analo