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Study of the relationship between nitrogen basicity and receptor affinity in a substituted quinoline series

✍ Scribed by M. B. Fleury; M. Largeron; D. Fleury; J. C. Vernieres

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
419 KB
Volume
79
Category
Article
ISSN
0022-3549

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✦ Synopsis

In buffered watermethanol media, the pK, values of acidbase equilibria involved in the protonation of substituted quinolines are determined by UV-visible absorption spectrometry. The observed behavior depends on the nature of RP: the N-CH, derivatives exist as quinoline, the N-H derivatives as 44minoquinoline tautomers. The irninoquinoline zwitterionic species present at physiological pH may have high receptor affinity. A linear relationship between pK, of the endocyclic nitrogen and log IC,, is discussed.

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