Study of the lipophilic character of xanthine and adenosine derivatives : I. RM and log P values

✍ Scribed by G.L. Biagi; M.C. Guerra; A.M. Barbaro; S. Barbieri; M. Recanatini; P.A. Borea; M.C. Pietrogrande

• Book ID: 104145646
• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 789 KB
• Volume: 498
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(01)84246-1

✦ Synopsis

The RM values of a series of xanthine and adenosine derivatives were measured using silicone reversed-phase thin-layer chromatographic (TLC) and C1 s reversedphase high-performance TLC systems. The two series of data were well correlated. Both were compared with experimental log P and calculated CLOGP values. For xanthine derivatives a good linear relationship was shown between the RM values from the two chromatographic systems and the log P or CLOGP data. For adenosine derivatives the CLOGP values had to be corrected in order to tit the data to the same equation. The TLC data proved to be reliable parameters for describing the lipophilic properties of the test compounds.

OF XANTHINES ANLI ADENUSINES. 1.