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Study of the interactions of D- and L-polylysine enantiomers with pectate in aqueous solutions

✍ Scribed by G. Paradossi; E. Chiessi; A. Malovíková

Publisher
Wiley (John Wiley & Sons)
Year
1999
Tongue
English
Weight
150 KB
Volume
50
Category
Article
ISSN
0006-3525

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✦ Synopsis

The interaction between D-and L-enantiomers of polylysine and potassium pectate was studied by means of CD, microcalorimetry, and osmometry. Upon binding with pectate, only poly (L-lysine) undergoes a coil to ␣-helix transition, while poly(D-lysine) remains in the disordered state. This suggest that the energetics of the interaction is influenced by stereochemical constraints besides electrostatic forces. Experimental findings from microcalorimetry suggest that a contribution to the overall enthalpy of binding comes from the polysaccharidic moiety. Stoichiometry of the macromolecular complexes studied by osmometry gives a polylysine : pectate ratio of 3 : 1, in agreement with the respective degree of polymerization of the two polyelectrolytes.

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