Study of the deletion mutation of glutathione transferase M1 gene and its role in susceptibility to hepatocellular carcinoma
β Scribed by Yun Ma; Zhuo-lin Deng; Yi-ping Wei
- Publisher
- Chinese Anti-Cancer Association
- Year
- 2001
- Tongue
- English
- Weight
- 237 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1000-9604
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π SIMILAR VOLUMES
The tumor suppressor gene CDKN2A (MTS1/p16), located on chromosome 9p21, is inactivated in a variety of tumors including melanomas and tumors of the biliary tract, pancreas, and stomach. The aim of the present study was to determine whether this gene is inactivated in hepatocellular carcinoma (HCC).
## Human chromosome band 16q24 commonly undergoes loss of heterozygosity (LOH) in human hepatocellular carcinoma (HCC). To further localize the region of deletion on 16q24 and to evaluate the genetic role of 17-beta-HSD, which is near 16q24, in HCC, we examined the pattern of loss of heterozygosity